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Simultaneous subependymomas in monozygotic female twins: further evidence for a common genetic or developmental

Susan Noell¹, Rudi Beschorner, Sotirios Bisdas

¹Departments of Neurosurgery.

Journal of Neurosurgery

|March 25, 2014

Abstract:

In this paper, a rare case of subependymoma of the fourth ventricle in identical female twins is reported. Magnetic resonance imaging and CT showed nearly identical locations of the tumors in the fourth ventricle and similar growth patterns of the tumors in both sisters. Likewise, postoperative histopathological analysis of both tumors revealed the typical histological appearance of subependymomas. Subependymoma is a rare, low-grade glioma of the CNS, slowly growing and usually asymptomatic. If symptomatic, a subependymoma can in some cases lead to sudden death caused by pressure on the brainstem or decompensated secondary hydrocephalus. This case demonstrates the importance of detecting tumors early and thereby preventing symptoms arising from increasing intracranial pressure, and optimizing therapy options.

Keywords:

GFAP = glial fibrillary acidic protein SNP = single nucleotide polymorphism familial tumor fourth ventricle genetics monozygotic twins oncology subependymoma

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