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Mechanisms of transformation by polyoma virus middle T antigen

D R Kaplan1, D C Pallas, W Morgan

  • 1Dana-Farber Cancer Institute, Boston, MA 02115.

Biochimica Et Biophysica Acta
|February 1, 1989
PubMed

Insights

Polyoma virus middle T antigen (MTAg) transforms cells by interacting with host proteins. This review explores MTAg

Area of Science:

  • Virology
  • Molecular Biology
  • Cellular Transformation

Background:

  • Polyoma virus middle T antigen (MTAg) lacks intrinsic biochemical activity.
  • MTAg is known to modulate host cell protein properties for transformation.

Purpose of the Study:

  • To elucidate the molecular mechanisms of MTAg-mediated cell transformation.
  • To review proteins interacting with MTAg and their role in transformation.

Main Methods:

  • Literature review of experimental data on MTAg-protein interactions.
  • Analysis of MTAg-associated cellular proteins, including pp60c-src, pp62c-yes, and phosphatidylinositol kinase.

Main Results:

  • MTAg transformation involves interactions with multiple host proteins.
  • Key interacting proteins include tyrosine kinase pp60c-src, pp62c-yes, and phosphatidylinositol kinase.

Conclusions:

  • Understanding MTAg-protein interactions is crucial for explaining cell transformation.
  • Biochemical details of MTAg and its associated proteins are assessed for their role in transforming properties of MTAg mutants.

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