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Systemic vascular inflammation in abdominal aortic aneurysm patients: a contrast-enhanced PET/CT study
S Morbelli1, G Ghigliotti, G Spinella
1Nuclear Medicine Unit IRCCS San Martino University Hospital, IST Dept of Health Sciences, University of Genoa, Genoa, Italy - silviadaniela.morbelli@hsanmartino.it.
Systemic vascular inflammation is present in asymptomatic abdominal aortic aneurysm (AAA) patients and linked to atherosclerosis risk factors. This highlights inflammation
Area of Science:
- Cardiovascular Imaging
- Vascular Biology
- Nuclear Medicine
Background:
- Atherosclerosis is a systemic inflammatory disease.
- Abdominal aortic aneurysm (AAA) is a manifestation of atherosclerosis.
- The role of systemic vascular inflammation in AAA is not fully understood.
Purpose of the Study:
- To investigate systemic vascular inflammation in asymptomatic AAA patients.
- To explore the relationship between vascular inflammation and atherosclerosis risk factors.
- To identify biomarkers associated with vascular inflammation in AAA.
Main Methods:
- Contrast-enhanced 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET/CT in 30 AAA patients and 30 controls.
- Assessment of inflammatory markers (CRP, ESR, WBC, fibrinogen, D-dimer, lipids).
- Quantification of arterial metabolism (TBR) and calcium load (CL); regression analysis.
Main Results:
- Elevated FDG uptake in aorta, carotid, and iliac arteries of AAA patients.
- AAA and aortic metabolism inversely correlated with HDL-cholesterol.
- Carotid metabolism correlated with monocyte count and C-reactive protein.
Conclusions:
- Systemic vascular inflammation is relevant in all stages of atherosclerosis.
- Acute ischemic events may stem from systemic inflammation, not just local lesions.
- Findings support a systemic inflammatory basis for atherosclerosis-related disorders.
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