Assessing cellular response to functionalized α-helical peptide hydrogels
Nazia Mehrban1, Edgardo Abelardo, Alexandra Wasmuth
1School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Advanced Healthcare Materials
|March 25, 2014
Abstract:
α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.
