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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
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Reservoir of Infection01:30

Reservoir of Infection

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Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
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Standard Precaution01:26

Standard Precaution

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Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Related Experiment Video

Updated: May 1, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

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Emerging Pathogens - How Safe is Blood?

Michael Schmidt1, Wolf-Jochen Geilenkeuser1, Walid Sireis2

  • 1Reference Institute for Bioanalytics, Bonn, Goethe University, Frankfurt/M., Germany.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|March 25, 2014
PubMed
Summary
This summary is machine-generated.

Blood transfusions pose risks from pathogens like malaria, dengue, Chagas disease, and Babesiosis. Universal pathogen inactivation offers a sustainable solution for blood safety against known and unknown infectious agents.

Keywords:
BabesiaBlood safetyChagas diseaseDengue virusMalaria

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Area of Science:

  • Transfusion Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Global mobility increases the risk of transfusion-transmitted infections beyond viruses.
  • Focus is shifting to other pathogens like malaria, dengue, Chagas disease, and Babesia spp.

Purpose of the Study:

  • To review the general infection risk of blood components for key transfusion-transmitted pathogens.
  • To highlight the limitations of current screening methods and the need for advanced solutions.

Main Methods:

  • Literature review of transfusion-transmitted pathogens.
  • Analysis of epidemiological data for malaria, dengue, Chagas disease, and Babesiosis.
  • Evaluation of current screening strategies and pathogen inactivation technologies.

Main Results:

  • Malaria, dengue, Chagas disease, and Babesiosis pose significant transfusion risks globally.
  • Screening assays exist but increase complexity and cost.
  • Pathogen inactivation presents a promising, sustainable approach.

Conclusions:

  • Enhanced blood safety requires addressing a broader range of transfusion-transmitted pathogens.
  • Universal pathogen inactivation systems are crucial for future blood safety.
  • Transfusion medicine awaits the implementation of such comprehensive systems.