Transformations of X (C, O, N)-CN Bonds: Cases of Selective X (C, O, N)-C Activation
Rui Wang1, John Russell Falck1
1Division of chemistry, Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA).
Abstract:
Activation of C-C, C-N, and C-O bonds has in recent decades been recognized as a valuable strategic objective. While considerable progress has been achieved, many of the more challenging issues, e.g., regioselective activation of specific C-X (C, O, N) bonds, chemoselective cleavage of C(sp3)-X bonds, enantioselective activation and even the successful application of solid catalysts in such transformations remain elusive. The research disclosed herein summarize recent advances in C-X bond cleavages, including regioselective processes, although the carbon is activated in the form of a cyano group.
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