Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liver cell rosettes: structural differences in cholestasis and hepatitis.

N Nagore1, S Howe, L Boxer

  • 1Department of Histopathology, Royal Free Hospital, School of Medicine, London, England.

Liver
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Randomized Hybrid Type I Effectiveness-Implementation Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Cancer (eREACH2): study protocol.

medRxiv : the preprint server for health sciences·2025
Same author

A Ducted, Biomimetic Nipple Improves Aspects of Infant Feeding Physiology and Performance in an Animal Model.

Dysphagia·2024
Same author

Recent Progress in Obstetrics and Gynæcology.

Buffalo medical and surgical journal·2023
Same author

Critical analysis of the Armed Forces Covenant Fund Trust Aged Veterans Fund.

BMJ military health·2021
Same author

The social and cultural meanings of infertility for men and women in Zambia: legacy, family and divine intervention.

Facts, views & vision in ObGyn·2020
Same author

Water extraction on Mars for an expanding human colony.

Life sciences in space research·2015
Same journal

Ubiquitin is a possible new predictive marker for the recurrence of human hepatocellular carcinoma.

Liver·2002
Same journal

Hepatic graft-versus-host disease resembling acute hepatitis: additional treatment with ursodeoxycholic acid.

Liver·2002
Same journal

Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.

Liver·2002
Same journal

Macro-aspartate aminotransferase in a female with antibodies to hepatitis C virus.

Liver·2002
Same journal

Cytotoxic response of sinusoidal endothelial cells to polymorphonuclear leukocytes and its potential implication in hypoxia-reoxygenation injury.

Liver·2002
Same journal

Early gene expression of hepatocyte growth factor in mononuclear phagocytes of rat liver after administration of carbon tetrachloride.

Liver·2002
See all related articles

Liver cell rosettes in cholestasis and hepatitis show distinct structures. Cholestatic rosettes may protect against bile injury, while hepatitis rosettes indicate liver cell regeneration after damage.

Area of Science:

  • Hepatology
  • Cell Biology
  • Pathology

Background:

  • Liver cell rosettes are observed in chronic cholestasis and chronic active hepatitis.
  • These structures represent cellular adaptations to liver injury.

Purpose of the Study:

  • To investigate differences in cytokeratin expression, ultrastructure, and 3-D configuration between cholestatic and hepatitic liver cell rosettes.
  • To understand the functional implications of these distinct rosette formations.

Main Methods:

  • Comparative analysis of cytokeratin expression.
  • Examination of ultrastructural morphology.
  • Three-dimensional (3-D) reconstruction and analysis.

Main Results:

  • Cholestatic rosettes exhibit characteristics of biliary metaplasia, connecting with bile ductules and potentially offering protection against bile constituents.

Related Experiment Videos

  • Hepatitis rosettes are identified as a regenerative response involving surviving hepatocytes in areas of liver collapse.
  • Distinct differences in cytokeratin expression and ultrastructure were observed between the two rosette types.

    • Conclusions:

    • Cholestatic and hepatitic liver cell rosettes are distinct structural modifications of hepatocytes in response to different types of liver injury.
    • Cholestatic rosettes suggest a protective biliary metaplasia, whereas hepatitis rosettes signify liver regeneration.