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Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
A medical diagnostic tool based on radial basis function classifiers and evolutionary simulated annealing.
Alex Alexandridis1, Eva Chondrodima1
1Department of Electronic Engineering, Technological Educational Institute of Athens, Agiou Spiridonos, Aigaleo 12210, Greece.
This study introduces an advanced neural network method, Evolutionary Simulated Annealing-Non-Symmetric Fuzzy Means (ESA-NSFM), for medical diagnosis. The ESA-NSFM algorithm significantly enhances classification accuracy and efficiency in analyzing medical records compared to traditional methods.
Area of Science:
- Artificial Intelligence
- Machine Learning
- Medical Informatics
Background:
- Medical records contain vast data valuable for decision support systems.
- Developing accurate, data-driven diagnostic tools is crucial for healthcare.
Purpose of the Study:
- To present a novel methodology for designing data-driven medical diagnostic tools using neural network classifiers.
- To adapt the Non-Symmetric Fuzzy Means (NSFM) algorithm for Radial Basis Function (RBF) classifiers and optimize them using Evolutionary Simulated Annealing (ESA).
Main Methods:
- Utilized Radial Basis Function (RBF) neural network architecture.
- Employed the Non-Symmetric Fuzzy Means (NSFM) training algorithm.
- Integrated the Evolutionary Simulated Annealing (ESA) technique for optimizing RBF models, enhancing the NSFM algorithm's ability to escape local minima.
Main Results:
- The ESA-NSFM algorithm demonstrated superior performance over standard RBF training and Support Vector Machines (SVMs) in accuracy and Matthews Correlation Coefficient (MCC) across nine benchmark datasets.
- The ESA-NSFM algorithm achieved statistically significant improvements in accuracy and MCC.
- The proposed approach exhibited faster computational times compared to SVMs.
Conclusions:
- The ESA-NSFM algorithm offers a robust, generic method for knowledge extraction from diverse medical records.
- This approach enhances diagnostic accuracy, outperforming existing classifier training methods.
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