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Sphenoid wing meningioma behavior on 11C-PiB and 18F-FDG PET
Hernan Chaves1, Yanina Bergamo, Santiago Paz
1From the Institute for Neurological Research Dr Raúl Carrea, Foundation Against Neurological Disease in Childhood (FLENI), Buenos Aires, Argentina.
Abstract:
Two patients with mild cognitive impairment underwent C-PiB and F-FDG brain PET. Both patients had previously gone through a contrast-enhanced MRI scan that revealed extra-axial tumors next to the sphenoid wing, suggestive of meningiomas. C-PiB PET images showed a highly increased uptake by the extra-axial masses. These 2 cases represent 1.2% of our C-PiB population (n = 163). No meningioma was found with negative C-PiB uptake. The F-FDG concentration was not increased within the lesions. C-PiB could be used as a meningioma marker.
Insights
Carbon-11 Pittsburgh Compound B (C-PiB) PET imaging revealed high uptake in meningiomas, suggesting its potential as a diagnostic marker. This contrasts with F-FDG PET, which showed no increased uptake in these tumors.
Area of Science:
- Neurology
- Nuclear Medicine
- Oncology
Background:
- Mild cognitive impairment can be associated with various underlying pathologies.
- Extra-axial tumors, such as meningiomas, can present incidentally or with neurological symptoms.
- Positron emission tomography (PET) tracers are utilized for in vivo molecular imaging of the brain.
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