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A biologic tissue adhesive for vitreoretinal surgery
D J Coleman1, B C Lucas, J A Fleischman
1Department of Ophthalmology, Cornell University Medical College, New York, New York 10021.
Retina (Philadelphia, Pa.)
|January 1, 1988
Summary
Researchers developed an autologous bioadhesive for retinal surgery. This innovative tissue glue creates chorioretinal adhesions, aiding in the repair of retinal detachments and tears.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Regenerative Medicine
Background:
- Commercially available tissue glue was evaluated for subretinal injection in rabbit eyes with induced retinal detachments.
- Initial results showed promising chorioretinal adhesions but identified limitations with pooled fibrinogen for human use.
Observation:
- An adhesive utilizing autologous plasma was developed as a substitute for pooled fibrinogen.
- This autologous bioadhesive was injected subretinally and intravitreally into rabbit and pig eyes.
- Histopathological evaluation confirmed circumscribed chorioretinal adhesions at the injection sites in both species.
Findings:
- The autologous bioadhesive successfully induced chorioretinal adhesions, crucial for retinal reattachment.
- Histologic examination confirmed the safety and efficacy of the bioadhesive in animal models.
- The bioadhesive demonstrated a short acting period of 4-6 days.
Implications:
- The autologous bioadhesive shows potential as an adjunct in vitreoretinal surgery for complex cases like macular holes and large retinal tears.
- Its ability to facilitate surgical procedures may improve outcomes in challenging ophthalmic conditions.
- Further investigation could establish this bioadhesive as a valuable tool in retinal surgical techniques.