Related Experiment Video

Updated: May 1, 2026

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
06:05

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection

Published on: October 12, 2017

15.3K

Renal cortical abnormalities in siblings of index patients with vesicoureteral reflux

Manuela Hunziker1, Eric Colhoun, Prem Puri

  • 1National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland; and.

Pediatrics
|March 26, 2014
PubMed

Insights

Screening siblings of children with vesicoureteral reflux (VUR) identified significant risks for renal cortical abnormalities. Previous urinary tract infections (UTIs) and high-grade VUR in siblings over one year old are key risk factors.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Genetics

Background:

  • Screening siblings of index patients with vesicoureteral reflux (VUR) aims to detect at-risk children and prevent renal damage.
  • The practice of sibling screening for VUR remains a subject of debate within the medical community.

Purpose of the Study:

  • To determine the prevalence of VUR and renal cortical abnormalities in siblings of VUR patients.
  • To identify independent risk factors for renal cortical abnormalities in this sibling cohort.

Main Methods:

  • A cohort of 318 siblings under 6 years old from families with VUR (grades III-V) was studied between 1998 and 2012.
  • Siblings were categorized based on a history of urinary tract infection (UTI) or routine VUR screening.
  • Logistic regression analysis identified risk factors for renal cortical abnormalities, including age, gender, UTI history, and VUR grade.

Main Results:

  • Vesicoureteral reflux (VUR) was detected in 60% of screened siblings and 40% of those with a UTI history.
  • Key independent risk factors for renal cortical abnormalities included a prior UTI (OR: 3.38), high-grade VUR (OR: 3.62), and age over 1 year (OR: 2.84).

Conclusions:

  • Siblings with a history of UTI, high-grade VUR, or those over one year old face an elevated risk of renal cortical abnormalities.
  • Findings aid in counseling families regarding the risks of VUR and reflux nephropathy in familial VUR cases.
Abstract

Keywords:
familial VURscreeningsiblingsvesicoureteral reflux

More Related Videos

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

3.0K
An Immature Murine Model of Reversible Unilateral Ureteral Obstruction06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

1.0K

Related Concept Videos

Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
3.5K
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
860
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
871
Disorders of the Urinary System01:20

Disorders of the Urinary System

The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
2.2K
Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
1.1K
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
558