Related Experiment Video

Updated: May 1, 2026

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

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p16INK4a, NAD(+) , and sestrins: new targets for combating aging-related chronic illness?

Helios Pareja-Galeano1, Fabian Sanchis-Gomar, Alejandro Lucia

  • 1Department of Physiology, Faculty of Medicine, Universidad de Valencia, Valencia, Spain; Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain.

Journal of Cellular Physiology
|March 26, 2014
PubMed

Insights

New research identifies novel therapeutic targets for age-related chronic illnesses, potentially improving functional independence and treating metabolic diseases in older adults.

Area of Science:

  • Gerontology and Geriatric Medicine
  • Pathology
  • Translational Medicine

Background:

  • Aging-related chronic illnesses are a significant burden, particularly for the oldest old.
  • These conditions impair functional independence and exacerbate other age-related diseases.
  • There is a critical need for effective therapies to mitigate age-related pathologies.

Purpose of the Study:

  • To highlight the clinical potential of recent basic research findings in aging.
  • To identify novel therapeutic targets involved in age-related pathologies.
  • To explore the application of these findings in treating age-related conditions, especially metabolic diseases.

Main Methods:

  • Review of recent provocative basic research in aging.
  • Identification and analysis of newly discovered therapeutic targets.
  • Assessment of the potential clinical implications of these targets.

Main Results:

  • Discovery of new therapeutic targets implicated in age-related pathologies.
  • Evidence suggests these targets may offer benefits for treating age-related conditions.
  • Potential positive impact on metabolic diseases associated with aging.

Conclusions:

  • Recent basic research offers promising new targets for age-related diseases.
  • These targets hold potential for improving healthspan and treating comorbidities.
  • Further investigation is warranted to translate these findings into clinical practice.

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