Related Experiment Video
Updated: May 1, 2026
11:31
Author Spotlight: Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells
Published on: May 12, 2023
1.6K
Linking membrane trafficking and intestinal homeostasis.
Eva Marie Y Moresco1, Katharina Brandl2
1Center for Genetics of Host Defense; UT Southwestern Medical Center; Dallas, TX USA.
Tissue Barriers
|March 26, 2014
Summary
Identifying new molecules is crucial for gut health. Yipf6 deficiency in mice causes intestinal inflammation, highlighting Yip family proteins
Area of Science:
- Microbiology and Immunology
- Molecular and Cellular Biology
- Gastroenterology
Background:
- Maintaining symbiotic relationships with intestinal bacteria is vital for host health.
- Numerous molecules contribute to intestinal homeostasis, but many remain undiscovered.
- Yip1 family proteins are implicated in endoplasmic reticulum (ER) to Golgi membrane transport.
Purpose of the Study:
- To identify novel molecules essential for intestinal homeostasis.
- To review recent advances in understanding Yip family members' roles in intestinal homeostasis.
- To explore the potential link between Yip molecule dysfunction and intestinal pathology.
Main Methods:
- Utilized a forward genetic approach to discover genes involved in intestinal homeostasis.
- Examined Yip1p-interacting protein 1 domain family, member 6 (Yipf6) null mutant mice.
- Assessed mouse models for hypersensitivity to dextran sulfate sodium (DSS)-induced colitis.
Main Results:
- A forward genetic screen identified several key molecules for intestinal homeostasis.
- Mice lacking Yipf6 exhibited increased susceptibility to DSS-induced colitis.
- Yipf6 null mutants developed spontaneous intestinal inflammation.
Conclusions:
- Yipf6 is a newly identified molecule critical for maintaining intestinal homeostasis.
- Yip family proteins likely play a significant role in regulating intestinal health.
- Dysfunction of Yip molecules may lead to intestinal inflammation and disease.
More Related Videos
09:24Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
Published on: February 11, 2021
7.2K
07:32An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
Published on: December 3, 2020
5.5K
Related Concept Videos
01:44Introduction to Membrane Traffic
7.8K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
7.8K
01:44Introduction to Membrane Traffic
3.0K
3.0K
01:23Transcellular Transport of Solutes
4.0K
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
4.0K
01:26Membrane Fluidity
14.0K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
14.0K
01:23Membrane Fluidity
150.1K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
150.1K
01:44The Significance of Membrane Transport
24.3K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
24.3K