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Claudins in teleost fishes
Dennis Kolosov1, Phuong Bui1, Helen Chasiotis1
1Department of Biology; York University; Toronto, ON, Canada.
Tissue Barriers
|March 26, 2014
Summary
Claudins (Cldns) are crucial tight junction proteins in teleost fish, regulating tissue permeability. This review summarizes their diverse roles in fish development and physiology.
Area of Science:
- Zoology
- Molecular Biology
- Fish Biology
Background:
- Teleost fish constitute nearly 50% of vertebrate species, highlighting their biological significance.
- Tight junctions (TJs) are vital cellular structures that control paracellular transport.
- Claudins (Cldns) are key transmembrane proteins within the TJ complex, largely dictating its permeability properties.
Purpose of the Study:
- To review and consolidate current knowledge on the claudin (Cldn) protein family in teleost fishes.
- To explore the diversity, tissue distribution, and functional roles of Cldns in teleosts.
- To emphasize the importance of Cldns in teleost embryonic development and physiological functions.
Main Methods:
- Literature review and synthesis of existing research on teleost claudins.
- Analysis of reported Cldn gene numbers and species distribution.
- Compilation of data on Cldn expression patterns and functional implications.
Main Results:
- Approximately 63 claudin genes have been identified across 16 teleost species.
- Claudins are expressed in a wide range of teleost tissues, with some exhibiting restricted patterns.
- Evidence indicates claudins are essential for teleost embryonic development and tissue/organ physiology.
Conclusions:
- Claudins are a diverse and vital protein family in teleost fishes.
- Their distinct expression patterns and barrier/pore-forming functions are critical for physiological homeostasis.
- Further research into teleost claudins will enhance understanding of vertebrate TJ complex evolution and function.
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