[Changes of postmortem human blood biochemical indexes]

Area of Science:

• Forensic Biochemistry
• Clinical Chemistry

Background:

• Accurate postmortem biochemical analysis is crucial for forensic investigations.
• Understanding biochemical index changes after death aids in determining cause and time of death.

Purpose of the Study:

• To investigate and analyze changes in postmortem human biochemical indexes.
• To assess the stability and fluctuations of various biochemical markers in postmortem blood.

Main Methods:

• Collected subclavian venous blood samples from 81 traffic fatalities.
• Analyzed 13 biochemical indexes: liver function (ALT, AST, TBIL, DBIL), renal function (UA, Cr), cardiac function (CK, CK-MB, LDH), electrolytes (K+, Na+, Cl-), and glucose (GLU).
• Utilized Roche cobas c311 analyzer and SPSS 17.0 for statistical analysis.

Main Results:

• Elevated levels and greater fluctuations observed in ALT, AST, CK, CK-MB, LDH, and K+.
• Relatively stable values with minimal fluctuations noted for TBIL, DBIL, UA, Cr, Na+, Cl-, and GLU.
• Enzymatic markers showed significant increases with higher standard deviations.

Conclusions:

• Postmortem biochemical indexes, especially enzymes, are significantly affected by factors like hemolysis and autolysis.
• Liver function, renal function, cardiac function, electrolyte, and glucose levels exhibit variable postmortem changes.
• Understanding these postmortem biochemical alterations is vital for accurate forensic interpretation.