Related Experiment Video

Updated: May 1, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

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MicroRNA-mediated regulation of melanoma

V Sun1, W B Zhou, S Majid

  • 1Center for Melanoma Research and Treatment, California Pacific Medical Center Research Institute, 475 Brannan St Suite 220, San Francisco, CA, 94107, U.S.A.

The British Journal of Dermatology
|March 27, 2014
PubMed

Insights

Melanoma, a deadly skin cancer, lacks effective treatments for advanced stages due to poorly understood molecular drivers. MicroRNAs (miRNAs) are key regulators in melanoma development and metastasis, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Dermatology

Background:

  • Melanoma is an aggressive skin cancer with high mortality, particularly in advanced stages.
  • Current treatments are limited, especially for metastatic disease, highlighting a need for better understanding of its molecular progression.
  • Genetic and epigenetic alterations are implicated in melanoma development and metastasis.

Purpose of the Study:

  • To review current data on microRNAs (miRNAs) involved in melanoma.
  • To highlight deregulated miRNAs targeting key genes and pathways in melanoma progression.
  • To discuss the potential clinical utility of miRNAs as biomarkers and therapeutic targets.

Main Methods:

  • Literature review of studies on miRNAs in melanoma.
  • Analysis of identified deregulated miRNAs and their targeted genes/pathways.
  • Evaluation of the role of miRNAs in melanocyte transformation and metastasis.

Main Results:

  • MicroRNAs (miRNAs) are emerging as critical regulators in melanoma initiation and progression.
  • Specific deregulated miRNAs target crucial genes and pathways driving melanoma development and metastasis.
  • miRNAs play a significant role in the transition from primary to metastatic melanoma.

Conclusions:

  • MicroRNAs are pivotal in melanoma pathogenesis and progression.
  • Targeting specific miRNAs holds promise for novel melanoma therapies.
  • miRNAs may serve as valuable biomarkers for early detection and prognosis of melanoma.

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