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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

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Published on: June 26, 2020

Genetic host specificity of hepatitis E virus.

James Lara¹, Michael A Purdy¹, Yury E Khudyakov¹

¹Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases

|March 27, 2014

Summary

Hepatitis E virus (HEV) genetic diversity influences host adaptation. Bayesian network analysis reveals coevolution among HEV protein sites, explaining its broad host range in humans and swine.

Keywords:

Adaptation Bayesian network Coevolution HEV ORFs Hepatitis E virus Prediction

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Published on: July 16, 2012

Area of Science:

Virology
Genetics
Evolutionary Biology

Background:

Hepatitis E virus (HEV) causes global hepatitis outbreaks.
HEV genotypes 3 and 4 (HEV3, HEV4) infect humans and swine, with swine as a key reservoir.
The role of HEV genetic diversity in host adaptation remains unclear.

Purpose of the Study:

To investigate the relationship between HEV genetic diversity and host specificity.
To identify coevolutionary patterns among HEV protein sites.
To determine if these patterns are associated with adaptation to human or swine hosts.

Main Methods:

Bayesian network (BN) analysis was used on HEV3 and HEV4 sequences.
Epistatic connectivity among protein sites was analyzed.
BN models were applied to individual proteins and nonstructural polyprotein domains.

Main Results:

Coevolution was detected among approximately 70% of polymorphic sites across all HEV proteins.
Numerous coevolving sites were linked to adaptation in swine or humans.
BN models accurately predicted host origin (74-93% for proteins, 63-87% for domains).

Conclusions:

HEV host specificity is a heritable, convergent trait.
Adaptation to different hosts can occur through various genetic pathways.
This explains the wide host range observed for HEV3 and HEV4.