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β-Cyclodextrin assisted solubilization of Cu and Cr complexes of flavonoids in aqueous medium: a DNA-interaction
Erum Jabeen1, Naveed Kausar Janjua1, Shahid Hameed1
1Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Abstract:
Cu and Cr complexes of three flavonoids (morin, quercetin and 6-hydroxyflavone) were synthesized and included in beta-cyclodextrin (βCD) with the objective of improving their pharmacokinetic profiles. Then binding with ds.DNA was studied to monitor their interactive tendencies at physiological conditions. The binding constants and other thermodynamic data from UV-vis spectroscopy and cyclic voltammetry revealed Cr-flavonoid-βCD to interact with ds.DNA at pH-7.4 through electrostatic mode of binding while Cu-flavonoid-βCD can intercalate into DNA. The strong binding propensity of Cu-flavonoid-βCD with ds.DNA encourages their application as anticancerous agent.
