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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Improving furosemide polymorphs properties through supramolecular complexes of β-cyclodextrin.
Claudia Garnero1, Ana Karina Chattah2, Marcela Longhi1
1Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA) CONICET-UNC and Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina.
Journal of Pharmaceutical and Biomedical Analysis
|March 27, 2014
Summary
New furosemide-cyclodextrin complexes enhance drug solubility and bioavailability. These supramolecular drug delivery systems show promise for pharmaceutical formulations.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Physical Chemistry
Background:
- Furosemide exhibits polymorphism, affecting its pharmaceutical properties.
- Cyclodextrins are known excipients for improving drug solubility and delivery.
- Understanding solid-state interactions is crucial for drug formulation development.
Purpose of the Study:
- To prepare and characterize β-cyclodextrin complexes with furosemide solid forms.
- To investigate the impact of complexation on furosemide solubility and bioavailability.
- To compare the efficacy of β-cyclodextrin with previously studied maltodextrin complexes.
Main Methods:
- Complexation via kneading and freeze-drying methods.
- Solubility studies in simulated gastric fluid.
- Solid-state characterization using ssNMR, FT-IR, DSC, TGA, SEM, and XRPD.
Main Results:
- Complexation significantly increased the solubility of furosemide form I.
- Enhanced solubility led to improved oral bioavailability.
- Characterization confirmed the formation of supramolecular complexes.
- β-cyclodextrin complexes demonstrated superior performance compared to maltodextrin complexes.
Conclusions:
- Novel furosemide-β-cyclodextrin supramolecular complexes offer potential for improved drug delivery.
- These complexes can enhance the bioavailability of furosemide, particularly form I.
- The findings support the application of these complexes in pharmaceutical formulations.
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