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Updated: Jul 18, 2025
10:10
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Cyclodextrins and Their Derivatives as Drug Stability Modifiers
Virginia Aiassa1, Claudia Garnero1, Ariana Zoppi1
1Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA-CONICET, Facultad Ciencias Químicas, Departamento de Ciencias Farmacéuticas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
Pharmaceuticals (Basel, Switzerland)
|August 26, 2023
Summary
Cyclodextrins (CDs) can stabilize or destabilize drugs through inclusion complex formation. Evaluating these effects in binary and multicomponent complexes is crucial for drug stability.
Area of Science:
- Pharmaceutical Science
- Supramolecular Chemistry
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides with hydrophobic cavities and hydrophilic exteriors.
- CDs form non-covalent inclusion complexes, often enhancing drug solubility and stability.
- However, CDs can also accelerate the degradation of certain drug molecules.
Purpose of the Study:
- To review studies investigating the dual role of cyclodextrin complexes in drug stabilization and destabilization.
- To highlight the influence of CD type and complex structure on drug stability.
- To discuss the impact of multicomponent complexes on drug stability.
Main Methods:
- Literature review of studies on cyclodextrin-drug interactions.
- Analysis of factors influencing drug stabilization and destabilization by CDs.
- Examination of binary and multicomponent complexation strategies.
Main Results:
- The effect of CDs on drug stability is highly dependent on the specific drug and the formed complex structure.
- Certain cyclodextrin types and complex architectures promote drug degradation.
- Auxiliary substances can be used to form multicomponent complexes, potentially modulating stability.
Conclusions:
- Careful evaluation of cyclodextrin complexation is necessary to predict and manage drug stability.
- Understanding inclusion complex structures is key to leveraging CDs for drug stabilization.
- Further research into multicomponent systems may offer improved strategies for enhancing drug stability.
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