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The versatile functions of ATM kinase

Rebecca J Boohaker, Bo Xu1

  • 1Department of Oncology, Drug Discovery Division, Southern Research Institute; Cancer Cell Biology Program, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.

Biomedical Journal
|March 27, 2014
PubMed

Insights

Ataxia-telangiectasia mutated (ATM) kinase is crucial for genome stability and DNA repair. This review covers ATM

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Ataxia-telangiectasia mutated (ATM) kinase is vital for maintaining genome stability.
  • ATM mutations cause the autosomal recessive disease ataxia-telangiectasia.
  • ATM signaling is essential for DNA double-strand break responses, including cell cycle checkpoints and DNA repair.

Purpose of the Study:

  • To review recent findings on the molecular mechanisms of ATM.
  • To discuss ATM's role in DNA damage response (DDR).
  • To explore ATM's functions in the mitotic spindle checkpoint and cancer metastasis.

Main Methods:

  • Literature review of recent studies on ATM kinase.
  • Analysis of molecular mechanisms in DNA damage response.
  • Examination of ATM's role in cell cycle checkpoints and cancer progression.

Main Results:

  • ATM is a central regulator of the DNA damage response.
  • ATM signaling extends beyond DNA repair to mitotic spindle checkpoint control.
  • Hyperactive ATM signaling is implicated in cancer invasion and metastasis.

Conclusions:

  • ATM kinase has diverse roles in maintaining genomic integrity and cellular processes.
  • Understanding ATM's non-canonical functions is critical for disease research.
  • Targeting ATM signaling may offer therapeutic strategies for cancer.

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