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Updated: Sep 23, 2026

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
Published on: June 17, 2020
The Mononuclear Phagocyte System: A Dispersed Organ; Introduction and Comments
Hsi-Hsien Lin1, Kirtana Sivasubramanian2, Annabell Roberti3
1Department of Microbiology and Immunology, Graduate Institue of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Anatomic Pathology, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Keelung, Keelung, Taiwan.
Abstract:
Mononuclear phagocytes are widely distributed throughout the body and interact with other cellular systems to preserve homeostasis and health. Recent studies have revealed the remarkable plasticity and adaptability of their cellular recognition and trophic responses beyond phagocytosis and immunity. We invited several early-career investigators to review the nature and interactions of selected Mononuclear Phagocyte populations within established organ systems, apart from lympho-haematopoietic tissues. This special issue indicates that the Mononuclear Phagocyte System (MPS) can be considered on a par with Neuro-Endocrine and other physiologic organ systems in the mouse and human. As a guide to the context of individual reviews, we provide a concise overview of the field and suggestions for further reading and research.
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