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Pulmonary involvement in Sjögren syndrome.
Maryl Kreider1, Kristin Highland2
1Division of Pulmonary, Allergy and Critical Care Department of Medicine Perelman School of Medicine of the University of Pennsylvania Philadelphia, PA.
Seminars in Respiratory and Critical Care Medicine
|March 27, 2014
Summary
Sjögren syndrome (SS) frequently affects the lungs, causing airway and interstitial lung diseases. Early detection of lung complications in SS patients is crucial for managing this chronic autoimmune condition.
Area of Science:
- Rheumatology
- Pulmonology
- Immunology
Background:
- Sjögren syndrome (SS) is a chronic autoimmune disorder targeting exocrine glands.
- Extraglandular manifestations are common in SS, with lung involvement affecting 10-20% of patients.
Purpose of the Study:
- To review the spectrum of lung involvement in Sjögren syndrome.
- To highlight common and rare pulmonary complications associated with SS.
Main Methods:
- Literature review of studies on Sjögren syndrome and lung disease.
- Analysis of clinical, radiological, and pathological findings in affected patients.
Main Results:
- Lung involvement in SS includes airway diseases like bronchiolitis and bronchiectasis.
- Interstitial lung diseases such as nonspecific, usual, and lymphocytic interstitial pneumonitis are observed.
- Increased risk of lymphoma and other rare lung abnormalities (amyloidosis, pulmonary hypertension) are noted.
Conclusions:
- Pulmonary complications are a significant feature of Sjögren syndrome, ranging from subclinical airway inflammation to severe interstitial lung disease.
- Comprehensive evaluation for lung disease is recommended in SS patients.
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