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Updated: May 1, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Hydroxycut-induced Liver Toxicity.

Dh Kaswala¹, S Shah¹, N Patel¹

¹Department of Medicine, University Hospital, Rutgers-New Jersey Medical School (Formerly UMDNJ-NJMS), Newark, NJ, USA.

Annals of Medical and Health Sciences Research

|March 27, 2014

Summary

This summary is machine-generated.

Weight loss supplements like Hydroxycut are unregulated and can cause liver damage. Discontinuing the supplement significantly improved a patient

Keywords:

Hydroxycut Liver toxicity Nutritional supplements

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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

Area of Science:

Hepatology
Pharmacovigilance
Toxicology

Background:

Nutritional supplements, particularly weight loss products, are widely used in the US despite lacking regulation.
Obesity is a significant public health issue, driving a large market for weight loss supplements.
Adverse health effects from these supplements are often underestimated by consumers, even with FDA advisories.

Observation:

A 27-year-old male presented with jaundice and right upper quadrant pain.
The patient was concurrently using Hydroxycut and other dietary supplements.
Laboratory tests revealed elevated liver enzymes, and liver biopsy confirmed drug-induced hepatotoxicity.

Findings:

Hydroxycut use was linked to severe liver injury (hepatotoxicity) in a case study.
The patient exhibited symptoms including jaundice and elevated liver enzymes.
Cessation of Hydroxycut led to a marked improvement in liver function and clinical symptoms.

Implications:

This case highlights the potential for hepatotoxicity from unregulated weight loss supplements like Hydroxycut.
It underscores the importance of monitoring and reporting adverse events associated with dietary supplements.
Healthcare providers should consider supplement-induced liver injury in patients with unexplained hepatotoxicity.