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Related Experiment Video

Updated: May 1, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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Overdetection in screening for prostate cancer.

Jonas Hugosson1, Sigrid Carlsson

  • 1aDepartment of Urology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden bDepartment of Surgery (Urology Service), Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Current Opinion in Urology
|March 28, 2014
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Summary
This summary is machine-generated.

Prostate cancer screening with prostate-specific antigen (PSA) testing leads to overdiagnosis. Strategies to reduce unnecessary prostate cancer detection include selective screening and active surveillance for low-risk tumors.

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Area of Science:

  • Urology
  • Oncology
  • Medical Screening

Background:

  • Prostate-specific antigen (PSA) testing has decreased prostate cancer mortality.
  • However, widespread PSA testing leads to overdiagnosis and overtreatment.

Purpose of the Study:

  • To describe mechanisms and extent of prostate cancer overdetection.
  • To identify strategies for avoiding unnecessary overdiagnosis.

Main Methods:

  • Review of current prostate cancer screening practices.
  • Analysis of overdetection rates associated with PSA testing and biopsy criteria.

Main Results:

  • Nonselective PSA testing and liberal biopsy criteria result in high overdiagnosis rates.
  • Overdiagnosis is a significant barrier to population-based prostate cancer screening.

Conclusions:

  • Decrease overdetection by screening selectively, avoiding unnecessary biopsies, and tailoring screening intervals.
  • Utilize MRI for biopsy selection and lesion-directed biopsies.
  • Treat only men who need treatment and consider active surveillance for low-risk tumors.