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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

177
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
177
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

315
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
315
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

137
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
137
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

172
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
172
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

164
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164

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Related Experiment Video

Updated: May 1, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Cell microenvironment stimuli-responsive controlled-release delivery systems based on mesoporous silica

Chun-Ling Zhu1, Xian-Wei Wang1, Zhen-Zhen Lin1

  • 1Department of Chemistry, Fuzhou University, Fuzhou, PR China.

Journal of Food and Drug Analysis
|March 29, 2014
PubMed
Summary

Mesoporous silica nanoparticles offer advanced drug delivery. This review highlights their use in stimuli-responsive systems targeting tumor microenvironments by responding to pH, glucose, ATP, GSH, and H2O2.

Keywords:
Cell environmentally responsive mechanismsControlled-release delivery systemMesoporous silica nanoparticlesStimuli-responsive

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Area of Science:

  • Materials Science
  • Biomedical Applications
  • Nanotechnology

Background:

  • Developing stimuli-responsive drug delivery systems is crucial for targeted cancer therapy.
  • Mesoporous silica nanoparticles (MSNs) are increasingly recognized for their drug-carrying capabilities.
  • MSNs offer unique characteristics for efficient and specific entrapment of therapeutic molecules.

Purpose of the Study:

  • To review recent advancements in mesoporous silica nanoparticles for drug delivery.
  • To focus on stimuli-responsive controlled-release systems utilizing MSNs.
  • To explore systems responding to specific tumor microenvironment triggers.

Main Methods:

  • Literature review of recent developments in MSN-based drug delivery.
  • Analysis of stimuli-responsive mechanisms in controlled-release systems.
  • Focus on nanoparticles responding to tumor-specific biomarkers and conditions.

Main Results:

  • MSNs demonstrate significant potential as drug carriers in biomedical applications.
  • Stimuli-responsive MSNs can be designed to release drugs in response to tumor microenvironment cues.
  • Key triggers include changes in pH, glucose, adenosine-5'-triphosphate (ATP), glutathione (GSH), and hydrogen peroxide (H2O2).

Conclusions:

  • Mesoporous silica nanoparticles are a promising platform for developing smart, controlled-release drug delivery systems.
  • Stimuli-responsive MSNs offer targeted therapeutic strategies by responding to the unique tumor microenvironment.
  • Further research in this area holds potential for improved cancer treatment outcomes.