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Signet-ring squamous cell carcinoma.

S F Cramer1, L M Heggeness

  • 1Department of Pathology, Rochester General Hospital, New York 14621.

American Journal of Clinical Pathology
|April 1, 1989
PubMed
Summary
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This study details the first reported case of signet-ring squamous cell carcinoma, a rare skin cancer variant. This aggressive cancer, originating from actinic keratosis, proved fatal for the patient.

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Signet-ring morphology is typically associated with adenocarcinoma, a glandular cancer.
  • Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, but rarely presents with signet-ring features.

Observation:

  • A case of poorly differentiated cSCC with a unique, invasive signet-ring component is presented.
  • Kreyberg stains were negative for mucin, ruling out adenocarcinoma.
  • Immunohistochemistry confirmed keratin within the signet-ring cells, characteristic of squamous differentiation.

Findings:

  • This is the first documented instance of signet-ring squamous cell carcinoma.
  • The tumor exhibited aggressive behavior, originating in a field of actinic keratosis.
  • The patient succumbed to the disease, highlighting the potential lethality of this rare variant.

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Implications:

  • This finding expands the known morphologic spectrum of cSCC.
  • It underscores the importance of thorough immunohistochemical analysis for accurate diagnosis.
  • Awareness of this rare variant is crucial for appropriate patient management and prognosis in cutaneous oncology.