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Long-term effects of substance P on the isolated guinea pig trachea
J Schreiber1, J Slapke, K Nieber
1Research Institute of Lung Diseases and Tuberculosis, GDR.
Biomedica Biochimica Acta
|January 1, 1988
Abstract:
The undecapeptide substance P(SP) and its C-terminal sequence SP-5-11 induced a dose-dependent contraction of the isolated guinea pig trachea. SP-5-11 had a more potent bronchoconstrictive action than SP-1-11. The distal part of the isolated guinea pig trachea showed a greater reagibility to SP-5-11 than the proximal one. There was a continuous increase of the amplitude of the SP-1-11-induced contractions when the neuropeptide was added several times at one-hour intervals. Incubation with 10(-6) M SP-1-11 for 5 h reduced the reagibility of the isolated guinea pig trachea to acetylcholine.