Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.1K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.2K
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Observational Study of Post-hip Fracture Outcomes in Older Adults with Type 2 Diabetes.

Journal of general internal medicine·2026
Same author

Contributions of Bone Microarchitecture to Skeletal Fragility in Adults with Longstanding Type 1 Diabetes.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Femora from adults with type 1 or type 2 diabetes have lower bone strength and smaller hip geometry.

JBMR plus·2026
Same author

Comparative Gastrointestinal Safety of Dulaglutide, Semaglutide, and Tirzepatide in Adults With Type 2 Diabetes.

Annals of internal medicine·2025
Same author

GLP-1RA and the risk of non-arteritic anterior ischaemic optic neuropathy in patients with type 2 diabetes: A population-based study.

Diabetes, obesity & metabolism·2025
Same author

The Association of Bone-related Biomarkers With Incident Hip Fracture: A Nested Case-control Study.

Journal of the Endocrine Society·2025

Related Experiment Video

Updated: May 1, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

1.4K

Bone metabolism after bariatric surgery.

Elaine W Yu1

  • 1Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|March 29, 2014
PubMed
Summary
This summary is machine-generated.

Bariatric surgery negatively impacts bone health, affecting bone density and metabolism. These skeletal effects persist long-term and differ based on the surgical procedure, necessitating further research into underlying mechanisms.

Keywords:
BARIATRIC SURGERYBIOCHEMICAL MARKERS OF BONE TURNOVERDXAOBESITY

More Related Videos

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

1.7K
Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

1.8K

Related Experiment Videos

Last Updated: May 1, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

1.4K
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

1.7K
Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

1.8K

Area of Science:

  • Endocrinology
  • Orthopedics
  • Metabolic Surgery

Background:

  • Bariatric surgery effectively treats severe obesity but poses risks to skeletal integrity.
  • Understanding the skeletal consequences of different bariatric procedures is crucial for patient management.

Purpose of the Study:

  • To review bone density and metabolism changes after bariatric surgery.
  • To analyze skeletal effects of Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB), and sleeve gastrectomy (SG).

Main Methods:

  • Comprehensive review of animal and clinical studies.
  • Consideration of skeletal imaging artifacts related to obesity and weight loss.

Main Results:

  • Bariatric surgery procedures demonstrate negative skeletal effects.
  • These effects are persistent, extending beyond one year post-surgery.
  • Skeletal impacts vary significantly among different surgical types (RYGB, AGB, SG).

Conclusions:

  • Bariatric surgery poses long-term skeletal risks.
  • Mechanisms of bone loss likely involve surgically induced hormonal and metabolic alterations.
  • Further research is needed to elucidate specific pathways and inform clinical recommendations.