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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Cell morphology in injectable nanostructured biosynthetic hydrogels.

Ortal Yom-Tov1, Dror Seliktar, Havazelet Bianco-Peled

  • 1Inter-Departmental Program for Biotechnology, Technion-Israel Institute of Technology, Haifa, 32000, Israel.

Journal of Biomedical Materials Research. Part A
|March 29, 2014
PubMed
Summary

This study introduces a novel nanostructuring technique for injectable hydrogels, enhancing their properties and influencing cell behavior for improved tissue engineering applications.

Keywords:
biomaterialscell morphogenesishydrogelinjectable scaffoldsnanostructuring

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Nanostructuring is crucial for tissue engineering scaffolds.
  • Existing nanostructuring methods are incompatible with injectable hydrogels.

Purpose of the Study:

  • To develop and evaluate a novel nanostructuring technique for injectable hydrogels.
  • To investigate the impact of nanostructuring on hydrogel properties and cell interactions.

Main Methods:

  • Covalently binding Pluronic® F127 molecules to biosynthetic hydrogels.
  • Analyzing scaffold properties (swelling, Young modulus).
  • Observing cell morphology and cell-material interactions in vitro.

Main Results:

  • Nanostructuring via bound Pluronic® F127 altered hydrogel properties.
  • Reduced swelling and increased Young modulus were observed, indicating crosslinking.
  • Spindled cell morphologies were noted at day 4, showing altered cell-material interaction.

Conclusions:

  • The novel nanostructuring technique is applicable to injectable hydrogels.
  • Nanostructuring significantly influences hydrogel mechanical properties and cell morphology.
  • This method offers a promising approach for advanced tissue engineering scaffolds.