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Updated: May 1, 2026
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
Suneela Pyreddy1, Pandurangan Dinesh Kumar1, Palanirajan Vijayaraj Kumar2
1Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.
Aim:
The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported.
Method And Materials:
About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol 600 using epichlorhydrin as linker. PEGylated 5.0 G PAMAM dendrimers loaded with Efavirenz (EFV) are evaluated for FTIR, DSC, SEM, drug release, and stability studies.
Results And Conclusion:
From the results it is proved that this method is less time consuming, inexpensive, and reproducible. Drug-release studies indicate, PEGylated 5.0 G PAMAM-EFV dendrimers have shown prolonged drug-release property.
