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Endometrial intraepithelial neoplasia
Richard A Owings1, Charles M Quick
1From the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Context:
Developed in conjunction with molecular and progression data, the sequence classification schema for endometrial intraepithelial neoplasia (EIN)/benign hyperplasia (BH) provides an easy to adopt and reproducible method for classification of endometrial biopsies.
Objective:
To review current data supporting the use of BH/EIN to classify endometrial biopsies, and to discuss the hormone-driven endometrial sequence from anovulation/disordered proliferative endometrium through BH and EIN and their diagnostic difficulty.
Data Sources:
A comprehensive review of EIN literature based on literature indexed by PubMed (National Library of Medicine) and Google Scholar.
Conclusions:
The BH/EIN schema is gaining wider acceptance among pathologist and clinicians. The research leading to the EIN criteria is based on molecular and progression data. The BH/EIN schema has better reproducibility among pathologists, is intuitively easy to use, and requires understanding of endometrial physiology and neoplasia.
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