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Two cases of multiple ossifying fibromas in the jaws
Ting-Ting Wang, Ran Zhang, Lin Wang1
1Department of Oral Medicine, Hebei United University, School and Hospital of Stomatology, Tangshan, 82 South Construction Road, Hebei 063000, Lubei District, PR China. wangl60@163.com.
Diagnostic Pathology
|April 1, 2014
Summary
Sporadic multiple ossifying fibromas (OFs) are rare and challenging to diagnose, requiring differentiation from HPT-JT syndrome. Testing for serum parathyroid hormone (PTH) and HRPT2 mutations is recommended for patients with multiple OFs.
Area of Science:
- Oral and Maxillofacial Pathology
- Endocrinology
- Genetics
Background:
- Multiple ossifying fibromas (OFs) present diagnostic challenges due to their rarity.
- Distinguishing sporadic multiple OFs from HPT-JT syndrome-related OFs and other fibro-osseous lesions is crucial.
Observation:
- This study analyzed 18 sporadic multiple OF cases and reviewed 24 HPT-JT related OF cases.
- Two sporadic multiple OF cases were analyzed for GNAS and HRPT2 mutations, with negative results.
- Demographic and radiographic features of sporadic multiple OFs were characterized, with a predilection for females and occurrence in both maxilla and mandible.
Findings:
- Sporadic multiple OFs constitute 2.0% of OF cases.
- No GNAS or HRPT2 mutations were identified in the sporadic multiple OF cases.
- HPT-JT related OFs showed a higher incidence of multiple jaw lesions (33.3%) compared to sporadic cases.
Implications:
- Early differentiation of sporadic multiple OFs from HPT-JT syndrome is vital for appropriate patient management.
- Serum PTH testing and HRPT2 mutation screening are strongly recommended for patients diagnosed with multiple ossifying fibromas.
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