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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Subjective well-being (SWB) refers to an individual's self-evaluation of their overall life satisfaction, happiness, and fulfillment. This multifaceted construct is typically assessed by analyzing the balance of positive and negative emotions alongside perceptions of life satisfaction. Personality traits such as neuroticism and extraversion are strongly associated with variations in SWB, offering critical insights into the underlying mechanisms of emotional well-being.
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Serotonin transporter and BDNF polymorphisms interact to predict trait worry.

Keith Bredemeier1, Christopher G Beevers, John E McGeary

  • 1a Providence Veterans Affairs Medical Center , Providence , RI , USA.

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|April 1, 2014
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Summary

Genetic factors influence excessive worry. The serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) genes interact to predict worry levels, suggesting a genetic basis for this common psychological trait.

Keywords:
5-HTTLPRBDNFCOMTgenetic associationworry

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Area of Science:

  • Behavioral Genetics
  • Psychiatric Genetics
  • Molecular Psychiatry

Background:

  • Excessive worry is linked to various psychological disorders.
  • Previous research has explored genes for anxiety, but not specifically for the general tendency to worry.
  • Understanding the genetic underpinnings of worry is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate the association between trait worry and functional polymorphisms in candidate genes.
  • To examine the roles of SLC6A4 (serotonin transporter-linked polymorphic region - 5-HTTLPR), BDNF (brain-derived neurotrophic factor - Val66Met), and COMT (catechol-O-methyltransferase - Val158Met) in trait worry.

Main Methods:

  • Genotyping of 173 adult participants for 5-HTTLPR, BDNF Val66Met, and COMT Val158Met polymorphisms.
  • Assessment of trait worry using the Penn State Worry Questionnaire (PSWQ).
  • Statistical analysis to test for associations and interactions between gene polymorphisms and worry levels.

Main Results:

  • A significant interaction was found between 5-HTTLPR and BDNF genotypes in predicting worry.
  • Short alleles of 5-HTTLPR were positively associated with higher PSWQ scores, but only in individuals carrying the BDNF met allele.
  • COMT genotype did not show a significant association with worry levels or interact with other genes.

Conclusions:

  • These findings offer preliminary insights into the genetic etiology of excessive worry.
  • The interaction between 5-HTTLPR and BDNF suggests a specific genetic pathway influencing worry.
  • Further research is needed to confirm these results and explore limitations.