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Catalytically Perfect Enzymes01:07

Catalytically Perfect Enzymes

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The theory of catalytically perfect enzymes was first proposed by W.J. Albery and J. R. Knowles in 1976. These enzymes catalyze biochemical reactions at high-speed. Their catalytic efficiency values range from 108-109 M-1s-1. These enzymes are also called 'diffusion-controlled' as the only rate-limiting step in the catalysis is that of the substrate diffusion into the active site. Examples include triose phosphate isomerase, fumarase, and superoxide dismutase.
 
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When in group settings, we are often influenced by the thoughts, feelings, and behaviors around us. Groupthink is another phenomenon of conformity where modification of the opinions of members in a group aligns with what they believe is the group consensus (Janis, 1972). In such situations, the group often takes action that individuals would not perform outside the group setting because groups make more extreme decisions than individuals do. Moreover, groupthink can hinder opposing trains of...
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Related Experiment Video

Updated: May 1, 2026

The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress
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Perfect--the enemy of good.

Michael L Boninger1, Lynn A Worobey1

  • 1University of Pittsburgh, School of Medicine, Pittsburgh, PA.

Archives of Physical Medicine and Rehabilitation
|April 1, 2014
PubMed
Summary

Wheelchair repairs are too frequent and have serious consequences for users, with the problem worsening. More research is needed to improve wheelchair design and support for users worldwide.

Area of Science:

  • Rehabilitation Engineering
  • Assistive Technology
  • Disability Studies

Background:

  • Frequent wheelchair repairs negatively impact users' daily lives and independence.
  • Existing studies on wheelchair maintenance and user impact are limited.
  • The need for improved wheelchair durability and repair services is growing.

Purpose of the Study:

  • To highlight the significant consequences of frequent wheelchair repairs for users.
  • To underscore the limitations of current research in this area.
  • To advocate for improved wheelchair design, maintenance, and research methodologies.

Main Methods:

  • Analysis of existing data on wheelchair repair frequency and user-reported consequences.
  • Review of current literature and commentary on wheelchair studies.

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  • Identification of limitations in current research approaches.

    • Main Results:

    • Wheelchairs require repairs more often than acceptable, leading to substantial user-related issues.
    • The problem of frequent repairs and their consequences is escalating.
    • Current research approaches are insufficient to address the complexity of the issue.

    Conclusions:

    • There is a critical need for more comprehensive research, including larger cohorts and enhanced methodologies.
    • Improvements in wheelchair design and repair services are essential.
    • Addressing these issues is crucial to positively impact millions of wheelchair users globally.