Related Experiment Video
Updated: May 1, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Fe-Catalysed oxidative C-H/N-H coupling between aldehydes and simple amides.
Jing Wang1, Chao Liu, Jiwen Yuan
1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. aiwenlei@whu.edu.cn.
An iron catalyst enables a new method for oxidative coupling of aldehydes and amides to form imides, likely via a radical pathway. This research introduces an efficient synthesis of imides using readily available starting materials.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Imides are valuable compounds in pharmaceuticals and materials science.
- Efficient synthetic routes to imides are crucial for chemical synthesis.
- Oxidative coupling reactions offer atom-economical pathways.
Purpose of the Study:
- To develop a novel catalytic method for synthesizing imides.
- To explore the use of iron catalysis in oxidative coupling reactions.
- To investigate the formation of imides from aldehydes and amides.
Main Methods:
- Utilized an iron catalyst for the oxidative coupling reaction.
- Employed various aldehydes and simple amides as substrates.
- Analyzed reaction products to confirm imide formation.
Main Results:
- Successfully achieved the oxidative coupling of aldehydes with amides.
- Synthesized a range of imides with good efficiency.
- The reaction likely proceeds through a radical mechanism.
Conclusions:
- Developed a novel iron-catalyzed method for imide synthesis.
- The proposed catalytic cycle involves a benzoyl halide intermediate.
- This method offers a new route for constructing imides from simple precursors.
More Related Videos
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
06:26Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO2 Source
Published on: August 17, 2018
Related Concept Videos
Acid-Catalyzed α-Halogenation of Aldehydes and Ketones
In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic...
C–C Bond Cleavage: Retro-Aldol Reaction
In the first step, as depicted in Figure 1, the base deprotonates the β-hydroxy ketone at the hydroxyl group to form an alkoxide ion.
Aldehydes and Ketones with Alcohols: Hemiacetal Formation
Aldol Condensation with β-Diesters: Knoevenagel Condensation
Preparation of Aldehydes and Ketones from Alcohols, Alkenes, and Alkynes
Aldehydes and Ketones with Amines: Enamine Formation Mechanism