Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

11.6K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
11.6K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

14.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.6K
Genetic Variation01:25

Genetic Variation

1.7K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.7K
Polytene Chromosomes02:04

Polytene Chromosomes

9.3K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
9.3K
Position-effect Variegation02:32

Position-effect Variegation

5.6K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
5.6K
Genome Copying Errors02:46

Genome Copying Errors

4.3K
DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: The non-coding RNA world in animals and plants.

Frontiers in genetics·2025
Same author

Multiple independent origins of the female W chromosome in moths and butterflies.

Science advances·2024
Same author

Maternal dominance contributes to subgenome differentiation in allopolyploid fishes.

Nature communications·2023
Same author

SilkMeta: a comprehensive platform for sharing and exploiting pan-genomic and multi-omic silkworm data.

Nucleic acids research·2023
Same author

High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecological adaptation.

Nature communications·2022
Same author

The Landscapes of Full-Length Transcripts and Splice Isoforms as Well as Transposons Exonization in the Lepidopteran Model System, <i>Bombyx mori</i>.

Frontiers in genetics·2021
Same journal

Mild oxidative stress and dietary epigenetic modulators direct DNA methylation remodeling toward stress-resilience pathways.

BMC genomics·2026
Same journal

Integrative ATAC-Seq and RNA-Seq analysis identifies key genes for intramuscular fat content in Laiwu pigs.

BMC genomics·2026
Same journal

A comprehensive long RNA landscape of multi-regional porcine lung-derived small extracellular vesicles.

BMC genomics·2026
Same journal

pGWAS-Portal: a comprehensive online platform for integrative post-genome-wide association study analysis.

BMC genomics·2026
Same journal

Physiological and transcriptomic analyses of Rosa persica in response to drought stress and functional validation of the transcription factor RpERF113-like.

BMC genomics·2026
Same journal

Integrated analysis of chromatin accessibility and transcriptome profiles in granulosa cells of sheep with different FecB genotypes.

BMC genomics·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Author Spotlight: Advancing Gene Silencing Research in Silkworms with dsRNA Delivery Through Feeding Chitosan Nanoparticles
05:36

Author Spotlight: Advancing Gene Silencing Research in Silkworms with dsRNA Delivery Through Feeding Chitosan Nanoparticles

Published on: October 4, 2024

2.2K

Copy number variations among silkworms.

Qian Zhao, Min-Jin Han, Wei Sun

  • 1Laboratory of Evolutionary and Functional Genomics, School of Life Sciences, Chongqing University, Chongqing 400044, China. zezhang@cqu.edu.cn.

BMC Genomics
|April 2, 2014
PubMed
Summary
This summary is machine-generated.

This study presents the first copy number variation (CNV) map for domesticated silkworms, identifying ~319 CNVs. These variations are linked to reproduction, immunity, and detoxification, offering insights into silkworm genome evolution.

More Related Videos

High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology
08:19

High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology

Published on: May 28, 2020

7.6K
An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants
09:32

An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants

Published on: November 8, 2017

7.3K

Related Experiment Videos

Last Updated: May 1, 2026

Author Spotlight: Advancing Gene Silencing Research in Silkworms with dsRNA Delivery Through Feeding Chitosan Nanoparticles
05:36

Author Spotlight: Advancing Gene Silencing Research in Silkworms with dsRNA Delivery Through Feeding Chitosan Nanoparticles

Published on: October 4, 2024

2.2K
High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology
08:19

High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology

Published on: May 28, 2020

7.6K
An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants
09:32

An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants

Published on: November 8, 2017

7.3K

Area of Science:

  • Genomics
  • Animal Genetics
  • Molecular Biology

Background:

  • Copy number variations (CNVs) are key drivers of genetic and phenotypic diversity.
  • CNVs are associated with diseases and quantitative trait loci (QTLs) in domesticated animals.
  • Knowledge of CNVs in silkworms remains limited.

Purpose of the Study:

  • To construct the first genome-wide map of CNVs in domesticated silkworm.
  • To characterize the distribution and genomic impact of silkworm CNVs.
  • To identify genes within CNVs and their potential functions.

Main Methods:

  • Genome-wide analysis of CNVs.
  • Next-generation sequencing.
  • Quantitative PCR (qPCR).

Main Results:

  • Identified approximately 319 CNVs, covering 10.8 Mb (2.3% of the genome).
  • Nearly half of the CNVs were located on uncharacterized chromosomes.
  • 61% of CNVs overlapped with segmental duplications (SDs).
  • Genes within CNVs are primarily involved in reproduction, immunity, detoxification, and signal recognition.

Conclusions:

  • An initial CNV map for silkworm has been established.
  • This map provides novel insights into silkworm genetic variations.
  • Silkworm CNVs likely play significant roles in reproduction, immunity, detoxification, and signal recognition.
  • The study offers valuable resources for insect genomics and understanding silkworm genome evolution.