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High prevalence of Helicobacter pylori infection in Behcet's disease

Kamran B Lankarani1, Mohammad Reza Ravanbod, Elham Aflaki

  • 1Health policy Research Center, Shiraz University of Medical Sciences, P,O, Box 71345-1414, Shiraz, Islamic Republic of Iran. lankaran@sums.ac.ir.

BMC Gastroenterology
|April 2, 2014
PubMed

Insights

Helicobacter pylori infection may play a role in Behcet's disease pathogenesis. Ongoing H. pylori infection was significantly more prevalent in Behcet's disease patients compared to controls.

Area of Science:

  • Gastroenterology
  • Immunology
  • Infectious Diseases

Background:

  • Behcet's disease (BD) is a multisystemic disorder with an unknown cause.
  • Emerging evidence suggests a potential link between Helicobacter pylori infection and BD pathogenesis.

Purpose of the Study:

  • To investigate the association between Helicobacter pylori infection and Behcet's disease.

Main Methods:

  • A case-control study was conducted comparing 48 BD patients with age- and sex-matched controls.
  • Helicobacter pylori infection was assessed using serology and the urea breath test (UBT).

Main Results:

  • Ongoing H. pylori infection was found to be more prevalent in BD patients than in controls.
  • The odds ratio for H. pylori infection in BD patients was 3.1 (95% CI: 1.34 - 7.26, P < 0.001).

Conclusions:

  • Helicobacter pylori infection is potentially implicated in the pathogenesis of Behcet's disease.
Abstract

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