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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
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Multiple sclerosis and pregnancy.

E Bodiguel1, C Bensa2, D Brassat3

  • 1Hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Service de neurologie, centre hospitalier Sainte-Anne, 1, rue Cabanis, 75014 Paris, France; Faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, 12, rue de l'École de Médecine, 75270 Paris cedex 06, France.

Revue Neurologique
|April 2, 2014
PubMed
Summary
This summary is machine-generated.

Pregnancy in women with multiple sclerosis (MS) is common. This think tank developed expert recommendations on managing MS during pregnancy, considering disease impact on both mother and child.

Keywords:
AccouchementAllaitementAnalgésie périduraleBreastfeedingClinical practice guidelinesConsensus formalisé d’expertsDeliveryEpidural analgesiaGrossesseMultiple sclerosisPregnancyRand Ucla appropriateness methodRecommandations de pratique cliniqueSclérose en plaques

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Area of Science:

  • Neurology
  • Obstetrics
  • Reproductive Health

Background:

  • Multiple sclerosis (MS) frequently affects women of reproductive age, necessitating guidance on pregnancy.
  • Existing literature lacks comprehensive recommendations for managing MS during pregnancy.
  • The Groupe de Réflexion sur la Sclérose en Plaques (GRESEP) identified a need for expert consensus on this topic.

Framework:

  • Formal expert consensus methodology was employed, mirroring previous GRESEP initiatives.
  • Recommendations were developed through a structured process involving a dedicated working group and a reading group.
  • The process ensured multidisciplinary input from neurologists, anaesthetists, and obstetricians.

Implementation:

  • A working group of hospital-based and private practice neurologists formulated the initial recommendations.
  • A reading group comprising neurologists, anaesthetists, and obstetricians reviewed and refined the recommendations.
  • Each recommendation is accompanied by its level of expert consensus.

Implications:

  • Provides evidence-based guidance for healthcare professionals managing pregnant patients with MS.
  • Aims to optimize outcomes for both women with MS and their infants.
  • Facilitates informed decision-making regarding family planning and pregnancy in the context of MS.