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The bromodomain: from epigenome reader to druggable target.

Roberto Sanchez1, Jamel Meslamani1, Ming-Ming Zhou1

  • 1Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Biochimica Et Biophysica Acta
|April 2, 2014
PubMed
Summary

Lysine acetylation, a key epigenetic mark, is recognized by bromodomains. Small molecules targeting this interaction offer new ways to control gene expression for diseases like cancer.

Keywords:
BromodomainGene transcriptionSmall molecule inhibitors

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