Related Experiment Video
Updated: May 1, 2026
05:51
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
26.2K
Do genetic mutations and genotypes contribute to onychomycosis?
Aditya K Gupta1, Fiona C Simpson, William C Brintnell
1Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ont., Canada.
Dermatology (Basel, Switzerland)
|April 2, 2014
Summary
Genetic factors influence susceptibility to onychomycosis, a fungal nail infection. Specific gene mutations and human leukocyte antigen types increase the risk of developing this common infection.
Area of Science:
- Immunogenetics
- Dermatology
- Mycology
Background:
- Individual susceptibility to onychomycosis varies despite similar environmental exposures.
- This suggests a potential genetic predisposition to dermatophyte infections.
Purpose of the Study:
- To identify genetic mutations or genotypes associated with onychomycosis.
- Investigate the genetic basis of susceptibility to fungal nail infections.
Main Methods:
- Literature search of the PubMed database.
- Focused on immune deficiencies linked to dermatophyte infections.
Main Results:
- Mutations in Dectin-1 and CARD9 are linked to familial mucocutaneous infections.
- Specific human leukocyte antigen genotypes correlate with higher onychomycosis prevalence.
- Reduced CD4+CD25+ regulatory T cells impair immune response, leading to chronic infections.
Conclusions:
- Documented genetic mutations and genotypes contribute to onychomycosis susceptibility.
- Genetic factors play a role in both familial and individual predisposition to fungal nail infections.
Related Concept Videos
01:20Mismatch Repair
5.4K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.4K
01:36Mismatch Repair
38.1K
Overview
38.1K
01:18Mutations in Microorganisms
1.2K
Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
1.2K
01:39Mutations
66.8K
Overview
66.8K
01:35Mutations
31.2K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
31.2K
01:39Mutations
11.0K
11.0K