Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

6.2K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.2K
The Bone Matrix01:18

The Bone Matrix

9.4K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
9.4K
Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Application of animal drugs in uro-andrological diseases under the guidance of diversified theories of traditional Chinese medicine].

Zhonghua nan ke xue = National journal of andrology·2025
Same author

Evolving trends in HPV vaccination coverage among women aged 9-45 in Chengdu, China: insights from 2017 to 2023.

Vaccine·2025
Same author

Utilizing multiplex reverse transcription-multiple cross displacement amplification-lateral flow biosensor technology for detecting H1N1, H3N2 and H7N9 influenza A virus subtypes.

Journal of virological methods·2025
Same author

Cucurbitacin B alleviates DSS-induced ulcerative colitis by improving gut microbiota disorder in C57BL/6 mice.

AMB Express·2025
Same author

Clinical value of transperineal prostate biopsy guided by cognitive fusion of magnetic resonance and transrectal ultrasound.

Medicine·2025
Same author

Rose-Mamba-YOLO: an enhanced framework for efficient and accurate greenhouse rose monitoring.

Frontiers in plant science·2025
Same journal

Capsanthin Attenuates Osteoporosis by Targeting the Urotensin II Receptor Pathway to Inhibit Oxidative Stress and NLRP3 Inflammasome Activation.

Calcified tissue international·2026
Same journal

ODAPH (p.Arg77*) Phenotype and Onset of Ameloblast Pathology During Postsecretory Transition Demonstrated by FIB-SEM Analyses of Odaph<sup>C41*/C41*</sup> Mice.

Calcified tissue international·2026
Same journal

Cytokine Networks Reprogramming the Osteo-Immune Microenvironment in Cancer Bone Metastasis.

Calcified tissue international·2026
Same journal

Associations between controlling nutritional status and mortality in osteoporosis: evidence from NHANES, 2005-2018.

Calcified tissue international·2026
Same journal

Gut Microbiota-Derived TMAO Drives MC3T3-E1 Senescence and Osteogenic Dysfunction via cGAS-STING-NF-κB Signaling: Implications for Age-Related Bone Loss.

Calcified tissue international·2026
Same journal

Artificial Intelligence Approaches for Osteoporotic Fracture Risk Prediction Using Administrative Health Data: A Systematic Review.

Calcified tissue international·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Propagation of Dental and Respiratory Cells and Organs in Microgravity
06:29

Propagation of Dental and Respiratory Cells and Organs in Microgravity

Published on: May 25, 2021

2.0K

Physiological effects of microgravity on bone cells.

Yasir Arfat1, Wei-Zhong Xiao, Salman Iftikhar

  • 1Key Laboratory for Space Biosciences & Biotechnology, Institute of Special Environmental Biophysics, Faculty of Life Sciences, Northwestern Polytechnical University, 127 Youyi Xilu, Xi'an, 710072, People's Republic of China.

Calcified Tissue International
|April 2, 2014
PubMed
Summary
This summary is machine-generated.

Microgravity during spaceflight causes bone mineral loss by affecting bone cell structures and functions. Understanding these cellular changes is crucial for mitigating bone density reduction in astronauts.

More Related Videos

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.3K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

2.0K

Related Experiment Videos

Last Updated: May 1, 2026

Propagation of Dental and Respiratory Cells and Organs in Microgravity
06:29

Propagation of Dental and Respiratory Cells and Organs in Microgravity

Published on: May 25, 2021

2.0K
Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.3K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

2.0K

Area of Science:

  • Space biology
  • Cellular biology
  • Bone physiology

Background:

  • Earth's life evolved under normal gravity (1g).
  • Microgravity in spaceflight impacts physiological processes, including bone mass and muscle integrity.
  • Bone adapts to mechanical loads throughout life.

Purpose of the Study:

  • To review recent research on bone cells under microgravity conditions.
  • To summarize advances in understanding microgravity's effects on bone.
  • To explore the mechanisms of bone loss in space.

Main Methods:

  • Review of in vitro and in vivo studies on bone cells.
  • Analysis of studies using real and simulated microgravity.
  • Examination of cell responses to altered mechanical stress.

Main Results:

  • Microgravity affects bone cell attachment structures and cytoskeletal organization.
  • Bone mineral loss is a significant problem associated with long-term weightlessness.
  • In vitro studies show modifications in bone cells exposed to spaceflight.

Conclusions:

  • The precise mechanisms of microgravity-induced bone loss require further elucidation.
  • In vitro models are valuable for studying bone cell mechanotransduction pathways.
  • Continued research is essential for addressing bone health during space missions.