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Updated: May 1, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Hoarseness misattributed to reflux: sources and patterns of error.
Many hoarse patients are misdiagnosed with reflux. Further laryngeal investigation is recommended for persistent hoarseness unresponsive to reflux treatment, revealing underlying voice disorders.
Area of Science:
- Otolaryngology
- Speech-Language Pathology
Background:
- Gastroesophageal reflux disease (GERD) is often implicated in voice disorders.
- Misattribution of hoarseness to reflux can delay accurate diagnosis and treatment.
Purpose of the Study:
- To identify voice disorders misdiagnosed as reflux.
- To determine the sources of misattribution in patients with hoarseness.
Main Methods:
- Retrospective chart review of 381 new patients with hoarseness.
- Analysis of 26 patients diagnosed solely with reflux seeking a second opinion.
- Exclusion of patients referred for further workup.
Main Results:
- Reflux alone was not the cause of hoarseness in any patient.
- Diagnoses included phonotraumatic lesions (42%), neurologic disorders (34%), age-related changes (19%), and infection (4%).
- Dynamic laryngeal examination with stroboscopy identified 85% of abnormalities, while flexible laryngoscopy identified only 15%.
Conclusions:
- Patients with hoarseness and no clear cause after initial evaluation, or those unresponsive to reflux treatment, may require advanced laryngeal investigation.
- Continued empiric reflux treatment or evaluation may be inappropriate for persistent dysphonia.
- Consider differential diagnosis beyond reflux for unexplained hoarseness.
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