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Celiac disease and risk of fracture in adults--a review
A M Hjelle1, E Apalset, P Mielnik
1Department of Rheumatology, Division of Medicine, District General Hospital of Førde, PO Box 1000, 6807, Førde, Norway, anja.myhre.hjelle@helse-forde.no.
Insights
Patients with celiac disease (CD) have a higher risk of fractures. Bone densitometry screening is recommended for adult CD patients to assess this fracture risk.
Area of Science:
- Gastroenterology
- Endocrinology
- Orthopedics
- Bone Metabolism
Background:
- Celiac disease (CD) is associated with reduced bone mineral density.
- The link between CD and increased fracture risk is not definitively established, leading to debate regarding routine bone density screening for all adult CD patients.
Purpose of the Study:
- To systematically review existing literature on the association between celiac disease and fracture risk.
- To evaluate the evidence supporting bone mineral density screening in adult celiac disease patients.
Main Methods:
- A comprehensive literature search was conducted using Medline and Embase databases.
- Included studies comprised cross-sectional cohort studies and case studies investigating fractures in patients with celiac disease.
Main Results:
- Despite study heterogeneity, the collective findings suggest a positive association between celiac disease and an elevated risk of fractures.
- The data indicates that individuals with CD are more prone to experiencing fractures.
Conclusions:
- Adult patients diagnosed with celiac disease should be considered for bone densitometry.
- Bone densitometry can aid in estimating fracture risk for proactive management in celiac disease patients.
Abstract:
Patients with celiac disease (CD) have low bone mineral density. Evidence of increased fracture risk in these patients is conflicting, and the indication for bone mineral density screening of all adult CD patients is debated. Our aim was to review current published data on fractures in CD. Cross-sectional cohort studies and one case study were identified by searching Medline and Embase. Although the identified studies are heterogeneous and difficult to compare, the overall findings indicate a positive association between CD and risk of fracture. Adult patients with CD should be considered for bone densitometry in order to estimate fracture risk.
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