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Medication adherence in gout: a systematic review.

Mary A De Vera1, Greg Marcotte, Sharan Rai

  • 1University of British Columbia Vancouver, and Arthritis Research Centre of Canada, Richmond, British Columbia, Canada.

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Summary

Medication nonadherence is a significant issue in gout management, with less than half of patients adhering to treatment in real-world settings. Healthcare providers should discuss medication adherence with patients during consultations.

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Area of Science:

  • Rheumatology
  • Pharmacology
  • Public Health

Background:

  • Medication nonadherence is a growing concern in gout management.
  • Understanding the burden, determinants, and impacts of nonadherence is crucial.

Purpose of the Study:

  • To systematically review literature on medication adherence in gout patients in real-world settings.
  • To synthesize the burden, determinants, and impacts of medication nonadherence in gout.

Main Methods:

  • Systematic literature search of multiple databases (Medline, Embase, etc.).
  • Selection of studies focusing on gout patients and medication adherence in real-world settings.
  • Extraction of data on study design, sample size, adherence measures, and determinants.

Main Results:

  • 16 studies were included, categorized by adherence measurement methods.
  • Adherence rates varied, with electronic prescription records showing rates below 0.80.
  • Older age and hypertension were associated with better adherence; one study linked adherence to serum uric acid target achievement.

Conclusions:

  • Less than half of gout patients demonstrate adherence to treatment in real-world settings.
  • Healthcare professionals must prioritize discussions about medication adherence during patient encounters.