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Targeting tropomyosin-receptor kinase fused gene in cancer

Yun Chen1, Sheng-Hong Tseng

  • 1Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan S. Rd., Taipei 100, Taiwan. shenghongtseng@gmail.com.

Anticancer Research
|April 3, 2014
PubMed

Insights

The Tropomyosin-receptor kinase fused gene (TFG) regulates protein secretion and cell proliferation. TFG fusion proteins are implicated in oncogenesis, but TFG

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Tropomyosin-receptor kinase fused gene (TFG) encodes a protein regulating protein secretion and intracellular trafficking.
  • TFG localizes to endoplasmic reticulum exit sites, controlling protein export.
  • TFG is involved in cell size, apoptosis, and proliferation regulation.

Purpose of the Study:

  • To review the functions and regulation of TFG and TFG fusion proteins.
  • To elucidate the role of TFG in tumorigenesis.
  • To discuss the potential of targeting TFG in cancer treatment.

Main Methods:

  • Literature review of TFG functions, regulation, and role in cancer.
  • Analysis of TFG's involvement in oncogenesis and tumor suppression.
  • Discussion of therapeutic strategies targeting TFG.

Main Results:

  • TFG fusion proteins are implicated in promoting tumor development.
  • TFG can act as an oncoprotein, but contradictory data suggests a tumor suppressor role.
  • TFG's dual role in tumorigenesis requires further investigation.

Conclusions:

  • TFG plays a complex role in cancer, acting as both an oncoprotein and potentially a tumor suppressor.
  • Understanding TFG's regulation and function is crucial for cancer therapy development.
  • Targeting TFG presents a potential therapeutic avenue for various cancers.
Keywords:
TRK-fused genecancerfusion proteinsreviewtumorigenesis

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