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Updated: May 1, 2026

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse
Published on: September 12, 2018
Christine E Coyle1, Julie Griffie, Lynn M Czaplewski
1Froedtert Lutheran Memorial Hospital Clinical Cancer Center, Milwaukee, Wisconsin. Christine E. Coyle, MSN, RN, OCN®, is a nurse educator at the Clinical Cancer Center-Day Hospital at Froedtert Lutheran Memorial Hospital in Milwaukee, Wisconsin. Her role is to improve nursing practice through standardization of continuing education and training for the specialty of oncology. Julie Griffie, MSN, RN, AOCN®, ACNS-BC, APRN, is the manager of nursing practice for the Clinical Cancer Center at Froedtert Lutheran Memorial Hospital in Milwaukee, Wisconsin. She has been a clinical nurse specialist for more than 30 years, specializing in oncology. She has written a number of publications related to nursing practice standards. Lynn M. Czaplewski, MS, RN, ACNS-BC, CRNI®, AOCNS®, is a clinical nurse specialist for the Cancer Center-Day Hospital at Froedtert Lutheran Memorial Hospital in Milwaukee, Wisconsin. She served as president of the Infusion Nurses Society from 2006 to 2007 and has been named CRNI® of the Year.
Chemotherapy extravasation, a serious safety issue causing tissue damage, was significantly reduced by a new clinical practice. This change minimized risks for cancer patients receiving vesicant agents.
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