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Elevated arterial stiffness and diastolic dysfunction in subclinical hypothyroidism

Mitsuru Masaki1, Kazuo Komamura, Akiko Goda

  • 1Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine.

Circulation Journal : Official Journal of the Japanese Circulation Society
|April 4, 2014
PubMed

Insights

Subclinical hypothyroidism is linked to increased arterial stiffness and impaired heart function. Higher NT-proBNP levels correlate with raised cardio-ankle vascular index (CAVI) in these patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Vascular Medicine

Background:

  • Thyroid hormone influences arterial stiffness and left ventricular diastolic function.
  • The specific relationship in subclinical hypothyroidism remains unclear.

Purpose of the Study:

  • To investigate the association between thyroid hormone levels, cardio-ankle vascular index (CAVI), and left ventricular diastolic function in subclinical hypothyroidism.

Main Methods:

  • Cross-sectional study comparing 83 untreated subclinical hypothyroidism patients with 83 controls.
  • Measured log NT-proBNP, CRP, arterial stiffness (CAVI), and early diastolic mitral annular velocity (E').

Main Results:

  • Subclinical hypothyroidism patients showed higher logNT-proBNP, CRP, and CAVI, and lower E' compared to controls.
  • CAVI was significantly associated with logNT-proBNP, CRP, and E' in the subclinical hypothyroidism group.

Conclusions:

  • Elevated NT-proBNP is associated with increased CAVI in subclinical hypothyroidism.
  • Subclinical hypothyroidism may increase cardiovascular event risk due to arterial stiffening and diastolic dysfunction.
Abstract

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