Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diffusion

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Protective effects of Silymarin on testicular torsion/detorsion in rats.

European review for medical and pharmacological sciences·2023

Same author

Impact of azole antifungal treatment on outcome in acute invasive fungal rhinosinusitis with orbitocranial involvement: a surgical perspective.

Rhinology·2023

Same author

Correction to: Endosymbionts Differentially Alter Exploratory Probing Behavior of a Nonpersistent Plant Virus Vector.

Microbial ecology·2022

Same author

The relationship between complete hydatidiform mole and serum Vitamin D level: a prospective case-control study.

European review for medical and pharmacological sciences·2022

Same author

The relationship between Vitamin A and Vitamin E levels and neonatal morbidities.

European review for medical and pharmacological sciences·2022

Same author

Proliferative verrucous leukoplakia: a clinicopathological comparative study.

International journal of oral and maxillofacial surgery·2022

Search research articles

Related Experiment Video

Updated: May 1, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Diffusion Reflection: A Novel Method for Detection of Oral Cancer.

D Fixler¹, R Ankri¹, I Kaplan²

¹Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, Israel.

Journal of Dental Research

|April 4, 2014

Summary

Diffusion reflection (DR) scanning with gold nanorods (GNRs) shows high sensitivity for detecting residual oral cancer. This method offers a promising tool for intraoperative identification of cancerous sites, potentially reducing recurrence rates.

Keywords:

early detection of cancer gold nanorods mouth neoplasms nanoconjugates nanospheres oral cancer

More Related Videos

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Related Experiment Videos

Last Updated: May 1, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Oral cancer recurrence is a significant clinical challenge.
Intraoperative detection of residual disease is crucial for improving patient outcomes.
Current methods for residual disease detection have limitations.

Purpose of the Study:

To evaluate the sensitivity of diffusion reflection (DR) measurements using bioconjugated gold nanorods (GNRs) for detecting oral squamous cell carcinoma.
To assess the potential of DR scanning as an intraoperative tool for identifying residual oral cancer.

Main Methods:

Oral squamous cell carcinoma was induced in a rat model using 4-nitroquinoline-N-oxide (4NQO).
Hyperspectral spectroscopy and DR measurements of GNRs were applied to excised tongue tissues.
Detection results were compared with histopathological findings.

Main Results:

GNRs selectively attached to cancerous sites with high specificity (97%) and sensitivity (87%).
DR scanning detected invasive cancer with >80% intensity increase and carcinoma in situ (CIS) with >30% increase.
Intensity differences between invasive cancer and CIS were statistically significant (p < .003).

Conclusions:

Direct DR scanning using bioconjugated GNRs is a sensitive and specific method for detecting oral cancer.
This technique shows great potential as a simple, novel tool for intraoperative residual disease detection.
Successful intraoperative detection can aid in reducing oral cancer recurrence rates.