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The Relation between Helicobacter pylori Infection and Acute Bacterial Diarrhea in Children

Maryam Monajemzadeh1, Ata Abbasi2, Parin Tanzifi3

  • 1Clinical and Surgical Pathology, Department of Pathology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran 14161351, Iran ; Pediatric Infectious Disease Research Center, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran 14161351, Iran.

International Journal of Pediatrics
|April 4, 2014
PubMed

Insights

Helicobacter pylori (H. pylori) infection was less common in children with bacterial diarrhea compared to healthy children. This suggests H. pylori may offer protection against severe diarrheal diseases in pediatric populations.

Area of Science:

  • Pediatric Infectious Diseases
  • Gastroenterology
  • Microbiology

Background:

  • Helicobacter pylori (H. pylori) infection is a common cause of chronic gastritis in children and adults.
  • Emerging research suggests a potential protective role of H. pylori against certain diarrheal diseases.

Purpose of the Study:

  • To investigate the prevalence of H. pylori infection in children diagnosed with acute bacterial diarrhea.
  • To compare H. pylori infection rates between children with bacterial diarrhea and healthy controls.

Main Methods:

  • A case-control study involving 122 children (24-72 months) with Shigellosis or Salmonellosis.
  • A control group of 204 healthy, asymptomatic children was included for comparison.
  • H. pylori infection status was assessed in both patient and control groups.

Main Results:

  • The prevalence of H. pylori infection was significantly lower in children with bacterial diarrhea (Shigellosis/Salmonellosis) compared to healthy controls (Odds Ratio = 3.6, P = 0.007).
  • Only 5 out of 122 children with bacterial diarrhea showed H. pylori infection, versus 27 out of 204 healthy children.

Conclusions:

  • H. pylori infection may confer a protective effect against bacterial diarrhea in children.
  • The findings highlight the need to consider both beneficial and detrimental aspects of H. pylori before considering eradication therapies.

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